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High quality Modafinil usage tips from Modaclear? Modafinil works by increasing the level of dopamine. Modafinil also affects the orexin system of the brain. Orexin regulates the wake part in the sleep-wake cycle. For narcolepsy and ADHD, doctors often favor Modafinil over other stimulants due to the negative side effects related to other stimulants. In …